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The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation
The Body Clock Protein BMAL1 Controls Protein Production When Activated by S6K1
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Abstract
The key circadian transcription factor BMAL1 promotes protein synthesis by associating with the translational machinery.
- BMAL1 interacts with components responsible for protein production in the cytosol.
- Ribosomal S6 protein kinase 1 (S6K1) rhythmically modifies BMAL1 through phosphorylation.
- This phosphorylation is essential for BMAL1's role in both connecting to the translational machinery and enhancing protein synthesis.
- Protein synthesis rates exhibit circadian patterns that rely on BMAL1.
- BMAL1's functions extend beyond transcription regulation to include a role in protein synthesis linked to the mTOR signaling pathway.
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