The Body Clock Protein BMAL1 Controls Protein Production When Activated by S6K1

The key circadian transcription factor BMAL1 promotes protein synthesis by associating with the translational machinery.

• BMAL1 interacts with components responsible for protein production in the cytosol.
• Ribosomal S6 protein kinase 1 (S6K1) rhythmically modifies BMAL1 through phosphorylation.
• This phosphorylation is essential for BMAL1's role in both connecting to the translational machinery and enhancing protein synthesis.
• Protein synthesis rates exhibit circadian patterns that rely on BMAL1.
• BMAL1's functions extend beyond transcription regulation to include a role in protein synthesis linked to the mTOR signaling pathway.

Simplified