How blood sugar and fat markers link long-term air pollution exposure to heart disease

An increase of 10 µg/m³ in particulate matter exposure is associated with elevated cardiovascular disease risk.

• 1,865 individuals were diagnosed with cardiovascular disease during a 7.4-year follow-up period.
• Average concentrations of particulate matter over three years before the baseline were 31.29 µg/m³ for PM, 56.03 µg/m³ for PM2.5, and 95.73 µg/m³ for PM10.
• Each 10 µg/m³ increase in PM exposure corresponded to hazard ratios of 1.135 for PM, 1.092 for PM2.5, and 1.075 for PM10 in relation to cardiovascular disease risk.
• TyG-related indicators, including TyG-BMI, TyG-WC, and TyG-WHtR, may partially mediate the association between particulate matter exposure and cardiovascular disease risk.
• Mediation proportions for these TyG-related indicators ranged from 5.54% to 15.30%.

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