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The mediating effect of TyG-related indicators between long-term exposure to particulate matter and cardiovascular disease: evidence from a national longitudinal cohort study
How blood sugar and fat markers link long-term air pollution exposure to heart disease
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Abstract
An increase of 10 µg/m³ in exposure is associated with elevated cardiovascular disease risk.
- 1,865 individuals were diagnosed with cardiovascular disease during a 7.4-year follow-up period.
- Average concentrations of particulate matter over three years before the baseline were 31.29 µg/m³ for PM, 56.03 µg/m³ for PM2.5, and 95.73 µg/m³ for PM10.
- Each 10 µg/m³ increase in PM exposure corresponded to hazard ratios of 1.135 for PM, 1.092 for PM2.5, and 1.075 for PM10 in relation to cardiovascular disease risk.
- -related indicators, including TyG-BMI, TyG-WC, and TyG-WHtR, may partially mediate the association between particulate matter exposure and cardiovascular disease risk.
- Mediation proportions for these TyG-related indicators ranged from 5.54% to 15.30%.
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Key numbers
1.135
Increase in CVD Risk per 10 µg/m³
Hazard ratio for exposure
13.18%
Mediation Proportion by -BMI
Mediation effect percentage
15.30%
Mediation Proportion by -WC
Mediation effect percentage