Endocrinology, diabetes & metabolism

Tirzepatide and SGLT2 Inhibitors for Heart Failure with Normal Pumping and Obesity: Moving Toward New Treatments for Heart and Metabolic Health

Updated

Abstract

Heart failure with preserved ejection fraction (HFpEF) accounts for over half of all heart failure hospitalizations.

  • Obesity is increasingly recognized as a central driver of HFpEF.
  • Expansion of epicardial adipose tissue is associated with HFpEF.
  • Chronic low-grade inflammation may contribute to the development of HFpEF.
  • Obesity-related haemodynamic overload could lead to ventricular hypertrophy in HFpEF patients.

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