Triclosan targeting of gut microbiome ameliorates hepatic steatosis in high fat diet-fed mice

Triclosan treatment at 400 mg/kg/d for 8 weeks significantly reduced lipid accumulation and alleviated hepatic steatosis in high fat diet-fed mice.

• Antibiotic use may regulate gut microbiota composition associated with non-alcoholic fatty liver disease (NAFLD).
• Triclosan suppressed pathogenic gram-negative bacteria, including Helicobacter, Erysipelatoclostridium, and Citrobacter.
• The treatment increased the ratio of Bacteroidetes to Firmicutes and enhanced the abundance of beneficial gut microbiomes like Lactobacillus and Bifidobacterium.
• Triclosan improved bacterial diversity and richness in high fat diet-fed mice.
• Pathway analysis indicated that triclosan may regulate nutrient and energy metabolism by eliminating harmful bacteria.

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