Effects of tryptophan-selective lipidated glucagon-like peptide 1 (GLP-1) peptides on the GLP-1 receptor

Both novel peptides, A and B, improved glucose tolerance and insulin sensitivity similarly to liraglutide under high-fat diet feeding.

• Peptides A and B increased cyclic adenosine monophosphate production and insulin secretion in vitro.
• Both peptides lowered blood glucose levels by boosting insulin levels after glucose intake.
• Peptide A activated satiety-promoting neurons and suppressed food intake and body weight comparably to liraglutide.
• Peptide B's effects on food intake and body weight were less pronounced than those of liraglutide.
• The long-term administration of both peptides improved glucose tolerance and insulin sensitivity, similar to conventional GLP-1 receptor agonists.

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