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Effect of upregulated renin–angiotensin system on per2 and bmal1 gene expression in brain structures involved in blood pressure control in TGR(mREN-2)27 rats
How an active blood pressure hormone system affects daily rhythm genes in brain areas controlling blood pressure in TGR(mREN-2)27 rats
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Abstract
In hypertensive TGR(mREN-2)27 rats, plasma renin activity levels were increased compared to controls.
- Circadian rhythms regulate cardiovascular functions over a 24-hour period.
- TGR rats exhibited an inverted blood pressure profile linked to an upregulated renin-angiotensin system.
- Clock gene expression of per2 showed a rhythmic pattern in most brain nuclei, peaking at night.
- Bmal1 expression reached its highest levels at the start of the day.
- Significant differences in clock gene expression were observed in the area postrema between TGR and control rats.
- The area postrema may be crucial for relaying peripheral signals to the central nervous system.
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