The Impact of Variants in Four Genes: MC4R, FTO, PPARG and PPARGC1A in Overweight and Obesity in a Large Sample of the Brazilian Population

In a study of 4,084 individuals, variants in three genes were significantly associated with overweight and obesity in the Brazilian population.

• The MC4R rs17782313-C variant was associated with obesity, particularly in women.
• The FTO rs9939609-A allele was linked to overweight, acting as a risk factor for women and a protective factor for men.
• The PPARG gene variant rs1801282-GG was strongly associated with both overweight and obesity, with the effect observed only in women.
• The combined effect of three risk alleles showed an increased likelihood of overweight and obesity, significant in females.
• These findings suggest a notable sex-specific genetic influence on the risk of obesity and overweight.

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