eNeuro

Daytime Wakefulness in Fruit Flies Linked to PDFR Signals to Dopamine Neurons

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated

Abstract

A subset of may promote wakefulness during the day through inhibition by pigment dispersing factor receptor signalling.

  • Large ventral lateral neurons (l-LN) are known to promote wakefulness via the neuropeptide pigment dispersing factor (PDF).
  • Small lateral neurons (s-LN) and dopaminergic neurons form synaptic connections with each other.
  • PDF receptor signalling inhibits dopaminergic neurons specifically during the daytime.
  • The interaction between PDF and its receptor may play a role in regulating sleep and wakefulness cycles.

Simplified

Key numbers

higher than controls
Increase in Daytime Sleep Duration
Mutants exhibit significantly higher daytime sleep compared to background controls.
6.53
6.53
One-way ANOVA results for downregulation of in .
43.81
43.81
One-way ANOVA results for overexpression of .

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