WNT Takes Two to Tango: Molecular Links between the Circadian Clock and the Cell Cycle in Adult Stem Cells

Dec 27, 2017Journal of biological rhythms

Molecular Connections Between the Body’s Daily Clock and Cell Division in Adult Stem Cells

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Abstract

Circadian rhythms may regulate cell divisions through intercellular connections involving WNT signaling.

  • Circadian clocks and cell cycles are interconnected biological systems that communicate with each other.
  • Recent findings suggest that Paneth cells influence the cell cycle in intestinal stem cells through signaling pathways.
  • This interaction highlights a shift from considering circadian regulation solely within individual cells to recognizing its effects in multicellular environments.
  • Understanding the molecular dynamics between these two oscillators could lead to identifying new targets for timing treatments effectively.

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