Zalsupindole is a Safe Brain-Boosting Drug with Treatment Effects Similar to Ketamine and Psychedelics

Zalsupindole produced robust effects on structural and functional neuroplasticity in the prefrontal cortex of rats.

• Zalsupindole is the first neuroplastogen administered to patients with major depressive disorder.
• The compound demonstrated sustained antidepressant-like responses in preclinical models.
• Effects on neuroplasticity from zalsupindole were comparable to or greater than those of ketamine, psilocybin, and dimethyltryptamine.
• Zalsupindole lacks the acute hallucinogenic and dissociative effects associated with other compounds.
• The findings suggest that zalsupindole could be a safer option for promoting neuroplasticity in treating depression.

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