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Anti-CRISPR-Associated Proteins Are Crucial Repressors of Anti-CRISPR Transcription
Proteins Linked to Anti-CRISPR Systems Are Key in Blocking Anti-CRISPR Gene Activity
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Abstract
An acr-associated promoter enables high levels of acr transcription immediately after phage DNA injection.
- Aca proteins repress acr transcription following phage DNA injection.
- High levels of acr transcription without Aca activity are lethal to phages.
- Acr proteins accumulate early during infection to inhibit host CRISPR-Cas systems.
- The conservation of aca genes suggests a protective role against the effects of acr promoters.
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