Full text is available at the source.
Autoreceptor Control of Peptide/Neurotransmitter Corelease from PDF Neurons Determines Allocation of Circadian Activity in Drosophila
Self-control of chemical release from clock neurons affects daily activity patterns in fruit flies
AI simplified
Abstract
PDF receptor activation in specific neurons shifts circadian activity from evening to morning.
- Drosophila melanogaster exhibits increased behavioral activity at dawn and dusk, regulated by central circadian clock neurons.
- The lateral-ventral pacemaker neurons (LN(v)s) secrete the neuropeptide PDF, which is involved in circadian behavior.
- PDF signaling is essential for organizing circadian activity in other clock neurons that express PDF receptors.
- Activation of PDF receptors in LN(v)s alters the timing of activity patterns, mimicking responses to summer-like conditions.
- This change is linked to stimulation of the Gα,s-cAMP pathway and adjusts the release of PDF and other neurotransmitters.
AI simplified