[Blood pressure lowering efficacy of telmisartan and amlodipine taking on the morning or at bedtime: ABPM results].

Blood pressure was significantly reduced in all treatment groups after 8 weeks of telmisartan and amlodipine administration.

• The decline in 24-hour systolic and diastolic blood pressure (SBP/DBP) was observed as follows: 29.94/16.32, 31.37/18.35, 29.49/17.30, and 25.80/15.51 mm Hg across four groups (P < 0.05 vs. baseline).
• No significant differences in the smooth index (SI) of 24-hour SBP/DBP were found among the groups (P > 0.05).
• Night-time blood pressure decline and distribution of dipper patterns were similar across treatment regimens at baseline and after treatment (all P > 0.05).
• The morning blood pressure surge (MBPS) decreased significantly in the group taking both medications at bedtime compared to other groups (P < 0.05).
• The efficacy of blood pressure lowering is independent of whether the medications are taken in the morning or at bedtime.

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