Comparison of the Efficacy of Morning Versus Evening Administration of Telmisartan in Essential Hypertension

Telmisartan administered at bedtime improved the sleep time-relative blood pressure decline toward a more dipper pattern, reducing nondipping prevalence by 76%.

• Bedtime dosing of telmisartan was more effective in reducing nocturnal blood pressure compared to morning dosing.
• The overall significant blood pressure reduction after 12 weeks of treatment was similar for both administration times.
• Sleep time-relative blood pressure decline was slightly reduced with morning dosing but significantly increased with bedtime dosing.
• Nocturnal blood pressure regulation is significantly better achieved with bedtime dosing.
• The administration time-dependent efficacy may be a characteristic of angiotensin receptor blockers.

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