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Brain glucocorticoid receptors are necessary for the rhythmic expression of the clock protein, PERIOD2, in the central extended amygdala in mice
Brain stress hormone receptors are needed for daily rhythms of the clock protein PERIOD2 in the emotion-related brain area of mice
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Abstract
Central deletion of the glucocorticoid receptor gene blunts the daily pattern of PER2 expression in specific brain regions.
- Corticosterone influences gene expression in neural and non-neural tissues.
- Rhythmic release of corticosterone is necessary for the daily expression of the clock protein PERIOD2 (PER2) in certain brain regions.
- Inactivation of the glucocorticoid receptor in neural tissues disrupts the expected daily PER2 expression pattern in the oval nucleus of the bed nucleus of the stria terminalis and central nucleus of the amygdala.
- No change in PER2 expression patterns was observed in the suprachiasmatic nucleus, basolateral amygdala, or dentate gyrus of the hippocampus.
- Findings suggest that brain glucocorticoid receptors regulate PER2 expression specifically in the BNSTov and CEA.
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