Neuroscience letters

Thyroid removal changes daily patterns of the clock protein PER2 in emotion and stress areas of the rat brain

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Surgical removal of the thyroid gland significantly altered the daily pattern of PER2 expression in the BNSTov and CEA of rats.

  • Thyroid hormones may play a role in regulating circadian clock genes.
  • Thyroidectomy/parathyrodectomy (TPX) affected PER2 expression in specific brain areas, including the oval nucleus of the bed nucleus of the stria terminalis (BNSTov) and the central nucleus of the amygdala (CEA).
  • No changes in PER2 expression were observed in the suprachiasmatic nucleus (SCN), basolateral amygdala (BLA), or dentate gyrus (DG) following TPX.
  • The findings suggest that the modulation of PER2 expression by thyroid hormones is tissue-specific.
  • The results indicate that thyroid hormones likely do not directly influence gene expression in all brain regions.

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