Thyroidectomy alters the daily pattern of expression of the clock protein, PER2, in the oval nucleus of the bed nucleus of the stria terminalis and central nucleus of the amygdala in rats

Sep 16, 2006Neuroscience letters

Thyroid removal changes daily patterns of the clock protein PER2 in emotion and stress areas of the rat brain

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Abstract

Surgical removal of the thyroid gland significantly altered the daily pattern of PER2 expression in the BNSTov and CEA of rats.

  • Thyroid hormones may play a role in regulating circadian clock genes.
  • Thyroidectomy/parathyrodectomy (TPX) affected PER2 expression in specific brain areas, including the oval nucleus of the bed nucleus of the stria terminalis (BNSTov) and the central nucleus of the amygdala (CEA).
  • No changes in PER2 expression were observed in the suprachiasmatic nucleus (SCN), basolateral amygdala (BLA), or dentate gyrus (DG) following TPX.
  • The findings suggest that the modulation of PER2 expression by thyroid hormones is tissue-specific.
  • The results indicate that thyroid hormones likely do not directly influence gene expression in all brain regions.

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