Motivational Modulation of Rhythms of the Expression of the Clock Protein PER2 in the Limbic Forebrain

Feb 10, 2009Biological psychiatry

Motivation changes daily patterns of the clock protein PER2 in emotion and memory brain areas

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Abstract

Daily rhythms in the expression of the clock protein Period2 (PER2) are observed in the limbic forebrain regions critical for motivation and emotion.

  • PER2 levels fluctuate rhythmically in the oval nucleus of the bed nucleus of the stria terminalis, central nucleus of the amygdala, basolateral amygdala, and dentate gyrus.
  • The suprachiasmatic nucleus acts as the primary circadian pacemaker that regulates PER2 expression in these regions.
  • Expression of PER2 is influenced by homeostatic changes and hormonal states that can directly affect motivated behavior.
  • Integration of circadian and homeostatic signals in the limbic forebrain may play a role in organizing motivational and emotional processes.

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