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Timed restricted feeding restores the rhythms of expression of the clock protein, Period2, in the oval nucleus of the bed nucleus of the stria terminalis and central nucleus of the amygdala in adrenalectomized rats
Timed restricted feeding restores daily patterns of a clock protein in stress and emotion brain areas of rats without adrenal glands
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Abstract
Adrenalectomy abolished the rhythms of the circadian clock protein Period 2 (PER2) in the limbic forebrain in normally fed rats but did not affect TRF-entrained PER2 rhythms.
- Timed restricted feeding (TRF) schedules synchronize the expression of PER2 in the limbic forebrain in rats.
- Adrenal glucocorticoids are known to influence circadian clock gene expression in peripheral tissues and certain brain regions.
- The study assessed the role of glucocorticoids in the regulation of PER2 expression induced by TRF.
- Results indicate that the TRF effect on PER2 rhythms is independent of adrenal glucocorticoids.
- The findings suggest that glucocorticoid involvement in PER2 regulation is region specific and state dependent.
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