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Chronotype-based radiotherapy in localised prostate cancer: protocol for a prospective cohort integrating MCTQ and salivary DLMO
Using body clock timing to plan radiation treatment for localized prostate cancer: study plan combining sleep habits and saliva hormone timing
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Abstract
A prospective observational cohort protocol evaluates whether chronotype-based radiotherapy timing reduces treatment-related toxicities in localized prostate cancer.
- Individual circadian phase is assessed using the Munich ChronoType Questionnaire and salivary dim-light melatonin onset.
- The primary endpoint focuses on late genitourinary toxicity grade ≥2 at 12 months.
- Secondary endpoints include gastrointestinal toxicity and patient-reported outcomes.
- The protocol is designed for multi-site adoption, indicating potential broader applicability.
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