Regulation of Circadian Clocks by Redox Homeostasis

Jul 18, 2013The Journal of biological chemistry

How balance of cell oxidation affects the body's internal clock

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Abstract

Circadian oscillations in the redox state of peroxiredoxin are conserved in both prokaryotes and eukaryotes.

  • Biological clocks in living organisms align with environmental cycles of light, temperature, and food availability.
  • Redox oscillations are identified as a non-transcriptional mechanism contributing to timekeeping alongside classical models.
  • Evidence suggests potential interactions between the circadian clock and the cell's redox status.
  • The relationship between the classical transcription-translation feedback loop and redox oscillation remains unclear.

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