Circadian redox oscillations and metabolism

Jun 27, 2015Trends in endocrinology and metabolism: TEM

Daily cycles of body chemical balance and metabolism

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Abstract

Circadian rhythms are 24-hour cycles that help organisms adapt to daily changes in their environment.

  • The molecular clockwork is primarily based on transcriptional processes involving negative feedback loops.
  • Non-transcriptional and metabolic oscillations also play a significant role in cellular timekeeping.
  • There is a relationship between the transcriptional oscillator and the metabolic redox state.
  • Disruptions in the synchronization of transcriptional and metabolic processes may be linked to various disorders, including cardiovascular and metabolic issues, aging, and cancer.

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