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Circadian clocks in human red blood cells
Daily biological rhythms in human red blood cells
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Abstract
Transcription is not required for circadian oscillations in humans, as shown using human red blood cells.
- Non-transcriptional events may be sufficient to sustain cellular circadian rhythms.
- Peroxiredoxins, antioxidant proteins, undergo approximately 24-hour redox cycles that persist for many days without external cues.
- The observed rhythms are entrainable, meaning they can be adjusted by environmental stimuli.
- The rhythms are also temperature-compensated, a characteristic feature of circadian rhythms.
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