Rethinking the clockwork: redox cycles and non-transcriptional control of circadian rhythms

Jan 24, 2014Biochemical Society transactions

Redox Cycles and Non-Genetic Controls in the Body's Daily Rhythms

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Abstract

Circadian cycles of oxidation and reduction are conserved across all domains of life.

  • Circadian rhythms are present in all living organisms, from bacteria to humans.
  • Traditionally, circadian rhythms have been explained by transcription-translation feedback loops (TTFLs).
  • New findings indicate that circadian rhythms can also occur through redox reactions, independent of transcriptional cycles.
  • Non-TTFL mechanisms may operate alongside genetic processes to produce recognizable circadian behaviors.

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