Molecular mechanisms of the circadian clockwork in mammals

Circadian rhythms are linked to metabolic processes, with disruptions potentially leading to clinical conditions.

• Molecular clocks that manage biological timing have evolved in nearly all organisms, suggesting a significant adaptive advantage.
• Being out of sync with the 24-hour cycle is associated with various clinical conditions, particularly those related to metabolic dysfunction.
• The core mechanism of circadian rhythms involves a feedback loop where specific genes regulate their own expression.
• Emerging evidence indicates that oscillations in redox reactions are interconnected with circadian rhythms and metabolic pathways.
• The interaction between transcriptional loops, redox processes, and metabolism in mammals may provide new avenues for disease treatment.

AI simplified