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Circadian control of metabolism and pathological consequences of clock perturbations
How the Body’s Internal Clock Regulates Metabolism and Health Problems from Its Disruption
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Abstract
Disruptions in biological clocks are associated with metabolic imbalances in mice.
- Most organisms possess an autonomous time-keeping system that regulates daily behavior and physiological processes.
- Biological clocks are influenced by light exposure and feeding cues, allowing adaptation to day/night and feeding/fasting cycles.
- Extended light exposure and unrestricted food availability may disturb these clocks, contributing to conditions like weight gain and insulin resistance.
- Research in mice indicates that clock disruptions can significantly affect metabolic regulation and whole-body homeostasis.
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