Circadian Clocks in Fuel Harvesting and Energy Homeostasis

Sep 6, 2011Cold Spring Harbor symposia on quantitative biology

Body’s internal clocks in managing energy use and fuel processing

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Abstract

Circadian systems optimize energy acquisition and storage in synchrony with the Earth's rotation.

  • Circadian clocks in plants regulate gene expression for photosynthesis during the day and nitrogen fixation at night.
  • In mammals, the core clock in the suprachiasmatic nucleus coordinates peripheral clocks with the light cycle.
  • Local clocks in the endocrine pancreas are involved in insulin secretion, highlighting their role in maintaining organismal balance.
  • Disruption of circadian rhythms may affect nuclear hormone receptor signaling and the regulation of metabolism.
  • Genetic studies suggest significant interactions between circadian and metabolic systems, influencing fuel use during the sleep-wake cycle.

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