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How the body's internal clock controls metabolism and energy use
Updated
Abstract
Circadian desynchrony may lead to metabolic pathologies such as obesity and diabetes.
- Circadian clocks in vertebrate cells align biological processes with the day/night cycle.
- Disruption of clock genes in mice affects metabolic functions in specific tissues during different phases of the sleep/wake cycle.
- Circadian desynchrony is commonly seen in shift work and sleep disruption among humans.
- There is an observed interrelationship among circadian disruption, sleep deprivation, obesity, and diabetes.
- Understanding these connections could inform rational therapeutic approaches for metabolic conditions.
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