Circadian Integration of Metabolism and Energetics

Dec 4, 2010Science (New York, N.Y.)

How the body's internal clock controls metabolism and energy use

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Abstract

Circadian desynchrony may lead to metabolic pathologies such as obesity and diabetes.

  • Circadian clocks in vertebrate cells align biological processes with the day/night cycle.
  • Disruption of clock genes in mice affects metabolic functions in specific tissues during different phases of the sleep/wake cycle.
  • Circadian desynchrony is commonly seen in shift work and sleep disruption among humans.
  • There is an observed interrelationship among circadian disruption, sleep deprivation, obesity, and diabetes.
  • Understanding these connections could inform rational therapeutic approaches for metabolic conditions.

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