The Journal of clinical investigation

How the Body's Daily Rhythms Affect Sleep and Metabolism

Updated

Abstract

The circadian gene network is present in most living organisms from eubacteria to humans.

  • Most cells and tissues express their own internal clocks.
  • Disruption of clock genes is associated with metabolic dysregulation.
  • Understanding the interactions between brain and peripheral clocks could enhance knowledge of energy balance.
  • Investigating molecular timing may lead to new therapeutic approaches for obesity and diabetes.

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