We can’t show the full text here under this license. Use the link below to read it at the source.
Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
Disrupted Body Clocks, Fat Tissue Metabolism, and Inflammation Control
AI simplified
Abstract
Circadian rhythm disruptions are associated with metabolic disturbances, including overweight and type-2 diabetes.
- Molecular circadian clocks synchronize daily behaviors and metabolism with the day-night cycle.
- Disruptions in circadian rhythms can lead to systemic low-grade inflammation, particularly in fat tissues.
- Genetic disruptions of circadian clocks in rodents result in metabolic issues similar to those seen in shift workers.
- Single-tissue circadian clocks play a crucial role in regulating metabolism.
- Behavioral interventions may help mitigate the negative metabolic effects of disrupted circadian rhythms.
AI simplified