Pflugers Archiv : European journal of physiology

How Disrupting the Body’s Internal Clock May Affect Metabolism

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

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Abstract

Circadian rhythms are linked to metabolism and may influence weight gain and cardio-metabolic disorders.

  • Circadian rhythms are driven by a central clock in the brain and various peripheral clocks in body tissues.
  • Disruption of circadian rhythms due to misalignment with environmental cues may lead to altered eating behavior.
  • Changes in circadian rhythms are associated with altered glucose and lipid metabolism.
  • Loss of synchronization between the internal clock and external signals can increase the risk of obesity, diabetes, and cardiovascular disease.
  • The review identifies gaps in knowledge regarding the molecular mechanisms and physiological significance of circadian rhythms in metabolism.

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