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Circadian actions of melatonin at the suprachiasmatic nucleus
Melatonin's daily effects on the brain's internal clock
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Abstract
Melatonin administration may entrain activity rhythms in both rodents and humans.
- The biological clock in the suprachiasmatic nucleus (SCN) regulates melatonin production by the pineal gland.
- Melatonin can influence circadian functions by feeding back on the SCN.
- Melatonin binds specifically to the SCN and alters its physiology through various mechanisms.
- The SCN shows a temporal restriction in sensitivity to melatonin, peaking during subjective dusk.
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