Differential regulation of circadian pacemaker output by separate clock genes in Drosophila

Mar 22, 2000Proceedings of the National Academy of Sciences of the United States of America

Different clock genes control daily rhythm signals in fruit flies

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Abstract

Mutations in the CLOCK and CYCLE transcription factors reduce PDF levels in small ventrolateral neurons by severely diminishing pdf RNA and neuropeptide production.

  • Specific clock genes regulate the pigment-dispersing factor (pdf) gene products in a unique cluster of brain cells.
  • Daily cycling of PDF is observed only in axon terminals, not in cell bodies or mRNA levels.
  • Period or timeless mutations eliminate the rhythmic expression of PDF in axon terminals without affecting overall PDF levels in cell bodies.
  • Different regulatory mechanisms are suggested for the pdf gene and its product within these important circadian neurons.
  • PDF is indicated as a significant mediator of circadian rhythms, functioning downstream of the central pacemaking machinery.

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