Circadian regulation of digestive and metabolic tissues

Disruption of the circadian clock is associated with exacerbated liver diseases, inflammatory bowel disease, and obesity.

• The circadian clock regulates 24-hour rhythms in behavior and physiology, including metabolic and digestive system activity.
• Light/dark cycles and feeding times help synchronize the circadian clock with the environment, which may enhance digestive health.
• Circadian clock genes influence the function of liver cells, gastrointestinal cells, and fat cells.
• Research indicates that disturbances in the circadian clock may contribute to the development of various digestive and metabolic diseases.
• Aligning digestive system function with the 24-hour day could improve prevention and treatment strategies for these diseases.

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