Effect of circadian rhythm type on serum lipid levels in shift workers: A 5-year cohort study

Apr 25, 2019Chronobiology international

How body clock type relates to blood fat levels in shift workers over 5 years

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Abstract

The regression coefficient of total cholesterol level in the 'definitely and moderately morning' group was -17.83 compared to the 'moderate evening' type.

Workers classified as 'definitely and moderately morning' experienced a significant reduction in total cholesterol compared to the 'moderate evening' group.
The 'intermediate' group also showed a lower total cholesterol level with a regression coefficient of -16.84 compared to the 'moderate evening' type.
Moderately evening type workers had higher total cholesterol and low-density lipoprotein (LDL) cholesterol levels than all other circadian rhythm types.
The 'intermediate type' group had a notable reduction in LDL cholesterol levels compared to the 'moderate evening type' group, with a regression coefficient of -16.08.
These findings suggest that evening-type circadian rhythm shift workers may be more prone to elevated serum lipid levels.

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We investigated how differences in circadian rhythm type affect the health of workers engaged in shift work. Employees, who were newly hired in a steel company between 2007 and 2011, received the Morningness-Eveningness Questionnaire (MEQ) survey. The target participants were 153 male shift workers who were not being treated with any antihyperlipidemic drugs and underwent periodic physical examinations including blood tests at least twice. According to the score of the MEQ at the time of joining the company, we classified the subjects into five types. Longitudinal changes in serum lipid level were estimated among the circadian rhythm types adjusted for age, BMI, and other covariates using a linear mixed model. The regression coefficient of total cholesterol level in the "definitely and moderately morning" group was -17.83 (95% confidence interval (CI): -33.42 to -2.23), and in the "intermediate 'group' was -16.84 [95% CI: -30.40 to -3.28], compared to the moderate evening type." The total cholesterol level was higher in the moderately evening type than in any of the other groups. Between the Morningness-Eveningness (ME) type and Low-density lipoprotein (LDL) cholesterol levels, compared with the "moderately evening type" group, the regression coefficient in the "intermediate type" group was -16.08 (95% CI: -28.79 to -3.37), and in the "definitely and moderately morning type" group was -17.50 [95% CI: -32.11 to -2.88]. The "moderately evening type" group had a higher LDL cholesterol level than any of the other groups. Evening-type circadian rhythm type shift workers are more prone to elevated serum lipid levels.

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Effect of circadian rhythm type on serum lipid levels in shift workers: A 5-year cohort study

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