Daily body clock patterns in metabolism and mental health influence each other, affecting metabolic and brain disorders

Circadian disruption is linked to impairments in glucose and lipid balance, neurotransmitter signaling, and stress response.

• Circadian rhythms regulate metabolism and brain function in alignment with the day-night cycle.
• Disrupted circadian rhythms can create a feedback loop that negatively affects both metabolism and brain health.
• Such disruptions are associated with conditions like obesity, diabetes, depression, and bipolar disorder.
• Recent advances suggest shared molecular mechanisms between circadian regulation, metabolism, and mental health.
• Understanding these connections could lead to circadian-based therapeutic strategies for metabolic and psychiatric disorders.

Simplified