Robustness and size dependence of circadian rhythms in multiscale suprachiasmatic-nucleus networks

Average period, amplitude, and synchronization of circadian rhythms remain stable across different scales of suprachiasmatic nucleus (SCN) networks.

• Size-dependent rhythmic activity observed in synthetic SCN networks does not occur in real SCN replicas.
• Increasing the average degree of a network correlates with the emergence of size-dependent rhythms.
• Low-degree networks tend to fragment and fail to maintain consistent rhythmic oscillations.
• Disruption of clustering self-similarity leads to a slight decrease in synchronization, but circadian rhythms are largely unaffected.
• The findings suggest that average degree is a more significant factor in sustaining rhythms than clustering.

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