Individuals with (CircS) have an adjusted odds ratio of 4.123 for developing (MASLD).
A significant association exists between CircS and MASLD.
Higher CircS scores correlate with increased risk of MASLD.
The association between CircS and MASLD remains consistent across different demographic groups.
CircS may aid in identifying individuals at higher risk for MASLD.
Further validation in prospective studies is needed to confirm the clinical utility of CircS in routine practice.
Simplified
BACKGROUND: (MASLD) is a prevalent chronic liver condition closely associated with metabolic syndrome and linked to circadian disruptions. (CircS), a constellation of metabolic and circadian dysregulations, has emerged as a risk factor for metabolic disorders. This study aims to examine the association between CircS and MASLD and to evaluate the potential relevance of CircS in identifying individuals at elevated MASLD risk.
METHODS: Data from 2,288 participants in the 2017-2018 U.S. National Health and Nutrition Examination Survey (NHANES) cycle were analyzed. Weighted logistic regression models were used to assess the overall association between CircS and MASLD. Restricted cubic spline (RCS) analyses were applied to evaluate the dose-response relationship. Subgroup analyses were conducted to explore potential effect modifiers underlying the CircS-MASLD association.
RESULTS: A significant association between CircS and MASLD was observed. Application of weighted logistic regression revealed that individuals with CircS had increased odds of MASLD (adjusted OR = 4.123, 95% CI: 2.489-6.832, P = 0.001) after adjusting for demographic, lifestyle, and metabolic covariates. The association was consistent across demographic subgroups, with a linear trend showing higher CircS scores correlating with increased MASLD risk.
CONCLUSION: CircS is significantly associated with MASLD and may have potential implications for early risk identification and targeted intervention. However, its clinical utility requires further validation in prospective studies before integration into routine practice.
Key numbers
4.123
Increased Odds of
Adjusted odds ratio for individuals with vs. without .
2,288
Study Participants
Total number of participants analyzed in the NHANES survey.
972 of 2,288
Prevalence
Number of participants identified with out of the total sample.
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Declarations. Ethics approval and consent to participate: The NHANES protocol was approved by the Research Ethics Review Board of the National Center for Health Statistics (NCHS), and informed consent was obtained from all participants. As NHANES data are de-identified and publicly available, this analysis did not require additional ethical review. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.
