Association of Life’s Essential 8 with metabolic dysfunction-associated steatotic liver disease (MASLD), a cross-sectional study from the NHANES 2003–2018

Jul 26, 2024Scientific reports

Links Between Life’s Essential 8 Health Measures and Fatty Liver Disease Related to Metabolism

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Abstract

Higher (LE8) scores are associated with lower odds of (MASLD).

A significant nonlinear dose-response relationship exists between LE8 scores and MASLD.
Blood glucose is identified as the most influential factor contributing to the risk of MASLD.
There are notable differences in the association between LE8 scores and MASLD based on age, educational level, and poverty income ratio.
The findings suggest an inverse correlation between lifestyle quality, as measured by LE8 scores, and MASLD risk.

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There is limited research on the relationship between (LE8) score and (MASLD). Our aim is to investigate the relationship between overall lifestyle assessed by LE-8 score and MASLD in a nationally representative sample. We employed the LE8 score to comprehensively evaluate cardiovascular health, the assessment of MASLD primarily utilized the Fatty Liver Index. The weighted logistic regression models, restrictive cubic splines (RCS), subgroup analyses and the weighted quantile sum (WQS) regression were used to evaluate the relationship between the cardiovascular health and MASLD. Logistic regression models revealed that higher LE8 scores were associated with lower odds of having MASLD. The RCS revealed a significant nonlinear dose-response relationship between LE8 scores and MASLD. The WQS regression model indicated that blood glucose contributed the most to the risk of MASLD. The subgroup analysis indicates that there are significant differences in this association across age, educational level, and poverty income ratio. Our study suggests that an inverse correlation between LE8 and the risk of MASLD. Our findings underscore the utility of the LE8 algorithm in MASLD risk assessment and provide support for MASLD prevention through the promotion of healthy lifestyles.

Key numbers

0.28

Odds Ratio for Moderate CVH

Compared to low cardiovascular health (CVH) group.

0.02

Odds Ratio for High CVH

Compared to low cardiovascular health (CVH) group.

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Association of Life’s Essential 8 with metabolic dysfunction-associated steatotic liver disease (MASLD), a cross-sectional study from the NHANES 2003–2018

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