Associations between life’s essential 8 and metabolic health among us adults: insights of NHANES from 2005 to 2018

Apr 7, 2024Acta diabetologica

Links between the Life's Essential 8 health factors and metabolic health in US adults from 2005 to 2018

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Among 22,582 participants, 73.5% were classified as having metabolic unhealth (MUH).

The median Life's Essential 8 (LE8) score for individuals with metabolic health was 73.75, compared to 59.38 for those with MUH.
Higher LE8 scores are associated with a lower risk of MUH, with an odds ratio of 0.53 for every 10-point increase.
A nonlinear dose-response relationship exists between LE8 scores and the likelihood of having MUH after adjusting for confounders.
The negative correlation between LE8 scores and MUH is more pronounced in older adults.
LE8 scores could serve as an alternative indicator for assessing metabolic health when detailed health behavior information is unavailable.

AI simplified

BACKGROUND: Metabolic unhealth (MUH) is closely associated with cardiovascular disease (CVD). Life's Essential 8 (LE8), a recently updated cardiovascular health (CVH) assessment, has some overlapping indicators with MUH but is more comprehensive and complicated than MUH. Given the close relationship between them, it is important to compare these two measurements.

METHODS: This population-based cross-sectional survey included 20- to 80-year-old individuals from 7 National Health and Nutrition Examination Survey (NHANES) cycles between 2005 and 2018. Based on the parameters provided by the American Heart Association, the LE8 score (which ranges from 0 to 100) was used to classify CVH into three categories: low (0-49), moderate (50-79), and high (80-100). The MUH status was evaluated by blood glucose, blood pressure, and blood lipids. The associations were assessed by multivariable regression analysis, subgroup analysis, restricted cubic spline models, and sensitivity analysis.

RESULTS: A total of 22,582 participants were enrolled (median of age was 45 years old), among them, 11,127 were female (weighted percentage, 49%) and 16,595 were classified as MUH (weighted percentage, 73.5%). The weighted median LE8 scores of metabolic health (MH) and MUH individuals are 73.75 and 59.38, respectively. Higher LE8 scores were linked to lower risks of MUH (odds ratio [OR] for every 10 scores increase, 0.53; 95% CI 0.51-0.55), and a nonlinear dose-response relationship was seen after the adjustment of potential confounders. This negative correlation between LE8 scores, and MUH was strengthened among elderly population.

CONCLUSIONS: Higher LE8 and its subscales scores were inversely and nonlinearly linked with the lower presence of MUH. MUH is consistent with LE8 scores, which can be considered as an alternative indicator when it is difficult to collect the information of health behaviors.

Full Text

Full text is available at the source.

View full text (PDF) ↗View full text (HTML) ↗

Associations between life’s essential 8 and metabolic health among us adults: insights of NHANES from 2005 to 2018

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief