Full text is available at the source.
A clock gene, period , plays a key role in long-term memory formation in Drosophila
The clock gene period is important for long-term memory in fruit flies
AI simplified
Abstract
per mutants exhibit a defect in long-term memory (LTM) formation in Drosophila melanogaster.
- CREB is essential for LTM formation and regulates the transcription of the circadian clock gene, period (per).
- Induction of a wild-type per transgene in per-null mutants rescues the LTM formation defect.
- Overexpression of per enhances LTM formation in wild-type flies.
- Synaptic transmission through per-expressing cells likely plays a role during the retrieval phase of LTM.
- Mutations in other clock genes, such as timeless, dClock, and cycle, do not impact LTM formation.
AI simplified