Life sciences

Changes in daily rhythm genes in blood cells of cancer patients having surgery

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Updated

Abstract

Plasma melatonin levels decreased in both groups throughout the day after surgery.

  • Expression of clock genes in peripheral blood mononuclear cells (PBMCs) was assessed in patients with esophageal and early gastric cancer.
  • The acrophase of hPer1 expression shifted significantly after surgery, indicating altered biological rhythms.
  • In patients with esophageal cancer, hPer1 acrophase changed from 6:19±1:50 to 13:59±0:59 (p=0.0003).
  • In patients with early gastric cancer, hPer1 acrophase changed from 7:47±1:27 to 12:33±1:30 (p=0.0043).
  • The acrophase of hPer2 expression also shifted significantly, from 5:01±2:59 to 19:30±2:15 (p<0.0001) in esophageal cancer patients.
  • Surgical stress may affect the biological clock and hormone levels in humans.

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