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Abstract
Patients treated with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may retain considerable gastric contents even after standard preoperative fasting.
- GLP-1 RAs are associated with delays in gastric emptying, potentially increasing the risk of pulmonary aspiration during general anesthesia.
- Short-acting GLP-1 RAs may cause more significant delays in gastric emptying compared to long-acting agents.
- Residual effects of long-acting GLP-1 RAs on gastric emptying could depend on dosage and treatment duration.
- Updated guidance from international anesthesia societies aims to address the risks associated with GLP-1 RAs in perioperative care.
- Current evidence on the aspiration risk related to GLP-1 RAs remains limited and inconsistent.
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