Skin-related effects of medications that activate glucagon-like peptide-1 receptors

GLP-1 receptor agonists may cause significant skin-related side effects, including injection-site reactions and hair loss.

• Injection-site reactions and immune-mediated responses, such as hypersensitivity and urticaria, are associated with GLP-1 receptor agonists.
• Facial fat loss, referred to as 'Ozempic face,' has been noted as a cosmetic effect related to these medications.
• Hair loss, particularly telogen effluvium, may occur and is potentially linked to rapid weight loss caused by GLP-1 receptor agonists.
• GLP-1 receptor agonists may have potential benefits for wound healing and treating inflammatory skin conditions like psoriasis.
• Clinicians are encouraged to monitor for dermatologic side effects in patients using GLP-1 receptor agonists and to refer to dermatology when necessary.

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