Mediating effect of diabetes in the association between long-term PM2.5 exposure and cancer risk in CHARLS

Feb 26, 2025Scientific reports

Diabetes may link long-term air pollution exposure to cancer risk in older adults

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Abstract

Data from 10,590 participants indicates significant associations between (PM) exposure, , and cancer incidence.

  • Long-term exposure to air pollutants, particularly PM, is linked to increased cancer risk.
  • Diabetes may act as a mediator in the relationship between PM exposure and cancer development.
  • Significant direct effects of PM on cancer incidence were confirmed through statistical analysis.
  • Conditional independence tests support the interaction between diabetes and PM in influencing cancer risk.
  • Specific air pollutants, including ammonium and nitrate, also show associations with cancer incidence.

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Key numbers

1.10
Cancer Odds Increase with
Odds Ratio for in relation to cancer risk.
10,590
Total Participants Analyzed
Number of individuals included in the study analysis.
45.1 µg/m
Average PM2.5 Level
Mean concentration of PM2.5 in the study population.

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