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Dim light at night induces depression-like behaviors during the postpartum period through circadian rhythm related pathways in mice
Dim light at night may cause depression-like behavior after birth by affecting the body's internal clock in mice
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Abstract
Dim light at night () significantly increased depression-like behaviors in postpartum mice.
- Pregnant mice exposed to dLAN showed reduced sugar preference and increased immobility, indicative of depression-like symptoms.
- dLAN exposure was associated with decreased levels of brain serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) during the postpartum period.
- The amplitude of circadian rest-activity behaviors and nighttime activity levels were diminished in mice exposed to dLAN.
- Disruptions in were linked to depression-like behaviors and lower levels of 5-HT.
- dLAN exposure altered the expression of circadian genes, particularly Per1, in the hippocampus of postpartum mice.
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Key numbers
2.614
Decrease in sucrose preference
Sucrose preference percentage between control and groups mice on PPD10-12.
2.852
Increase in immobility time
Immobile time (s) during FST between control and groups mice on PPD14.
3.848
Lower serotonin concentration
5-HT concentration in the brain.