Journal of biochemistry

Separate brain locations of daily rhythm and FMRFamide signals in houseflies and fruit flies

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Abstract

cDNA cloning of an fmrf mRNA from the housefly Musca domestica was achieved.

  • FMRFamide-like peptides and PDF were previously suggested to coexist in the same cells in insect brains.
  • Double-labelled in situ hybridization showed that the fmrf and pdf mRNAs are expressed in distinctly different cells in housefly brains.
  • Similar findings were confirmed in the fruit fly Drosophila melanogaster, indicating separate expression of these neuropeptides.
  • The results suggest that FMRFamide and PDF peptides are unlikely to be released from the same neurons.

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