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Electrical Hyperexcitation of Lateral Ventral Pacemaker Neurons Desynchronizes Downstream Circadian Oscillators in the Fly Circadian Circuit and Induces Multiple Behavioral Periods
Over-activating side pacemaker neurons disrupts timing signals and causes multiple behavior cycles in the fly's daily rhythm system
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Abstract
Functional ablation of the LNV clock neurons in Drosophila abolishes circadian rhythms of locomotor activity.
- Hyperexcitation of LNVs through transgenic methods leads to the decomposition of behavioral rhythms into multiple independent oscillations.
- Clock protein oscillations in specific dorsal neuron subgroups are phase-shifted when LNVs are hyperexcitable.
- Regulated electrical activity of LNVs is associated with the synchronization of multiple oscillators in the circadian pacemaker circuit of flies.
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