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Estradiol regulates daily rhythms underlying diet-induced obesity in female mice
Estradiol controls daily body rhythms linked to diet-related obesity in female mice
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Abstract
Ovariectomized female mice with undetectable circulating estrogens became obese and displayed disrupted daily rhythms when fed a high-fat diet.
- Estradiol is associated with the regulation of circadian rhythms in females, contributing to their resistance to diet-induced obesity.
- High-fat diet feeding in ovariectomized females resulted in altered liver molecular circadian rhythms.
- Restoring estradiol levels in ovariectomized females fed a high-fat diet improved their eating behavior and activity patterns.
- Time-restricted feeding in ovariectomized females helped maintain daily eating rhythms and reduced obesity and insulin resistance.
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