Ovarian hormones protect female mice from daily rhythm disruptions caused by a high-fat diet

Female mice maintained robust daily rhythms of eating and activity while on a high-fat diet for 1 week.

• C57BL/6J female mice did not develop obesity from a high-fat diet over 8 weeks, unlike male counterparts.
• High-fat feeding did not disrupt the daily eating and locomotor activity rhythms in female mice.
• The liver molecular timekeeping rhythm (PER2:LUC) remained unchanged in female mice despite high-fat feeding.
• Ovariectomized female mice showed reduced amplitudes in eating and activity rhythms during high-fat feeding.
• In ovariectomized females, high-fat feeding advanced liver PER2:LUC rhythms by approximately 4 hours.

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