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Estrogen differentially regulates expression of Per1 and Per2 genes between central and peripheral clocks and between reproductive and nonreproductive tissues in female rats
Estrogen changes daily gene activity differently in brain and body clocks and in reproductive versus non-reproductive tissues of female rats
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Abstract
Chronic treatment with 17beta-estradiol (E2) altered the expression of clock-related genes in ovariectomized rats.
- E2 treatment advanced the peak of Per2 gene expression in the brain's suprachiasmatic nucleus.
- E2 did not affect the rhythm of Per2 or Per1 gene expression in the cerebral cortex.
- In nonreproductive tissues such as the liver and kidney, E2 delayed the phase and increased the amplitude of Per1 gene expression.
- Biphasic rhythms in Per1 and Per2 gene expression were observed in the uterus after E2 treatment.
- The effects of estrogen on gene expression differ between central and peripheral clocks in the brain, as well as between reproductive and nonreproductive tissues.
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